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Content archived on 2024-05-24

Genetics of predisposition to radiation-induced cancer of the thyroid

Objective

Carcinoma of the thyroid is a serious public health problem in populations at risk of exposure to radio nuclides accumulating in thyroid tissue. However, due to genetically determined differences in individual susceptibility to ionising radiation, simple dose-response relationships do not exist. Identification of those subjects who are predisposed to developing thyroid tumours would be of value for setting individual exposure limits and for tailoring post-exposure monitoring. The GENRAD-T consortium aims to identify the gene loci that are responsible for determining individual susceptibility to thyroid cancer. To do this we will use a mouse model of radio iodine-induced thyroid cancer combined with molecular genetic screening methods (QTL-mapping, micro satellite allelotyping and CGH). The applicability of the gene loci thus identified for use in human populations will be confirmed by analysing human thyroid tumours.

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Coordinator

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
EU contribution
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Address
Ingolstädter Landstrasse 1
85764 Neuherberg bei München
Germany

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Participants (3)

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