The overall objective of this proposal is to examine the aetiology of pre-menopausal breast cancer after the Chernobyl accident. Specific objectives are to evaluate the role of radiation and genetic modifiers in increases in breast cancer incidence in Belarus and Ukraine and to study the possible interaction between radiation exposure and genetic alterations in genes (BRCA1, BRCA2, ATM) known to influence radiation sensitivity and the risk of breast cancer development.
The proposed project consists of 5 closely interrelated workpackages:
1 - Descriptive epidemiology of breast cancer in contaminated areas of Belarus and Ukraine;
2 - Establishment and testing of mechanisms and procedures for the proposed case-control study;
3 - Phased implementation of the case-control study;
4 - Molecular analysis of BRCA1, BRCA2 and ATM;
5 - Development and testing of dose reconstruction method.
Funding SchemeCSC - Cost-sharing contracts