Gene radiation interaction: their influence on pre-menopausal breast cancer risk after chernobyl

Objective

The overall objective of this proposal is to examine the aetiology of pre-menopausal breast cancer after the Chernobyl accident. Specific objectives are to evaluate the role of radiation and genetic modifiers in increases in breast cancer incidence in Belarus and Ukraine and to study the possible interaction between radiation exposure and genetic alterations in genes (BRCA1, BRCA2, ATM) known to influence radiation sensitivity and the risk of breast cancer development.

The proposed project consists of 5 closely interrelated workpackages:
1 - Descriptive epidemiology of breast cancer in contaminated areas of Belarus and Ukraine;
2 - Establishment and testing of mechanisms and procedures for the proposed case-control study;
3 - Phased implementation of the case-control study;
4 - Molecular analysis of BRCA1, BRCA2 and ATM;
5 - Development and testing of dose reconstruction method.

Fields of science

• medical and health sciences › health sciences › public health › epidemiology
• medical and health sciences › clinical medicine › oncology › breast cancer

Programme(s)

• FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002)

Topic(s)

• 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

Address

150,cours Albert-thomas 150
69372 Lyon
France

Participants (3)

BELARUSSIAN CENTER FOR MEDICAL TECHNOLOGIES, COMPUTER SYSTEMS, ADMINISTRATION AND MANAGEMENT OF HEALTH

Belarus

Address

P. Brovki Str.
220600 Minsk

FINNISH CANCER REGISTRY

Finland

Address

21b,liisankatu 21b
00170 Helsinki

INSTITUTE OF ONCOLOGY - ACADEMY OF MEDICAL SCIENCES OF UKRAINE

Ukraine

Address

Lomonosova, 33/43
03022 Kyiv