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Gene radiation interaction: their influence on pre-menopausal breast cancer risk after chernobyl

Objective

The overall objective of this proposal is to examine the aetiology of pre-menopausal breast cancer after the Chernobyl accident. Specific objectives are to evaluate the role of radiation and genetic modifiers in increases in breast cancer incidence in Belarus and Ukraine and to study the possible interaction between radiation exposure and genetic alterations in genes (BRCA1, BRCA2, ATM) known to influence radiation sensitivity and the risk of breast cancer development.

The proposed project consists of 5 closely interrelated workpackages:
1 - Descriptive epidemiology of breast cancer in contaminated areas of Belarus and Ukraine;
2 - Establishment and testing of mechanisms and procedures for the proposed case-control study;
3 - Phased implementation of the case-control study;
4 - Molecular analysis of BRCA1, BRCA2 and ATM;
5 - Development and testing of dose reconstruction method.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
Address
150,Cours Albert-thomas 150
69372 Lyon
France

Participants (3)

BELARUSSIAN CENTER FOR MEDICAL TECHNOLOGIES, COMPUTER SYSTEMS, ADMINISTRATION AND MANAGEMENT OF HEALTH
Belarus
Address
P. Brovki Str.
220600 Minsk
FINNISH CANCER REGISTRY
Finland
Address
21B,liisankatu 21B
00170 Helsinki
INSTITUTE OF ONCOLOGY - ACADEMY OF MEDICAL SCIENCES OF UKRAINE
Ukraine
Address
Lomonosova, 33/43
03022 Kyiv