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Genetic pathways for the prediction of the effects of irradiation - European normal and tumour tissue bank

Objective

In synergy with RTD Project GENEPI 1, a tissue bank, including lymphocytes and skin biopsies and a database will be created as essential infrastructure for present and future genetic research in the field of radiation protection and health. From normal tissues obtained from up to 2000 individuals (GENEPI-1) RNA,
DNA and proteins will be extracted, frozen, catalogued and stored. Networking systems and IT for normalisation and storage of data in a central database, including gene expression profiles and a web-based information /access system will be established. Modern statistical tools and high throughput computational biology will be applied for multiplexed data processing and analysis. Protocols for use and access will be developed and ethical and legal issues addressed. The tissue bank will remain open for 10 years until tissues from at least 10000individuals have been collected.
The overall aim of the project is to create & maintain a collection of frozen normal tissues from the participating partners in WP4 of GENEPI-1.This bank will serve as a source of biological material for determination of genes, proteins, and molecular pathways responsible for the variation of normal tissue response to radiation. The bank will preserve material such that DNA, RNA & proteins that can be isolated and applied to the recent and continuing developments in genomics, proteomics & bio informatics. This includes techniques such as DNA sequencing, expression profiling with micro-arrays, single-nucleotide polymorphism (SNP) &mass-spectrometry protein analysis. In parallel an IT infrastructure linking the research institutes, including a web-based access & information system, will be developed and a database set up containing clinical, tissue & genetic data.

Funding Scheme

THN - Thematic network contracts

Coordinator

EUROPEAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY
Address
Av. E. Mounier, 83/4
1200 Bruxelles
Belgium

Participants (5)

DRESDEN UNIVERSITY OF TECHNOLOGY
Germany
Address
Fetscherstrasse 74
01307 Weissig - Dresden
EUROPEAN ORGANIZATION FOR RESEARCH AND TREATMENT OF CANCER
Belgium
Address
125,Avenue E.mounier 83
1200 Bruxelles
FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN
France
Address
Rue Juliette Dodu 27
75010 Paris
GRAY LABORATORY CANCER RESEARCH TRUST
United Kingdom
Address
Mount Vernon Hospital
HA6 2JR Northwood
UNIVERSITY HOSPITAL GASTHUISBERG
Belgium
Address
Herestraat 49
3000 Louvain / Leuven