Objective
Phagocytosis is the uptake by cells of large particles into vacuoles. During this process, newly formed phagosomes fuse with endosomes and lysosomes. The Griffiths group has established the use of latex beads with macrophages as a model for studying phagocytosis, and set up an in vitro fusion assay between phagosomes and endocytic organelles. Several data suggest a role of actin in the phagosome-endosome fusion. I propose to characterize membrane and actin interactions, by identifying membrane proteins of the phagosome which directly or indirectly bind actin. The major proteins will be identified using high resolution 2D gel electrophoresis, and a collaboration could be set up with groups having expertise in molecular biology. This line of research will allow to more understand some steps in phagocytosis which plays a central role during host defense against infective agents.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences biological sciences molecular biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
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