Objective
The sudden appearance of calcified skeletons among many different invertebrate taxa at the Precambrian/Cambrian transition may have required minor reorganizations of pre-existing secretory products, in particular mucous substances of the epithelial tissues. In the Late Proterozoic, muci would have prevented spontaneous calcium carbonate overcrusting of soft tissues exposed to the supersaturated ocean, a function that we define as 'anti-calcification'. In the Early Cambrian times, the inhibiting substances of the muci would have been reorganized to form skeletal matrices.
The hypothesis that skeletal matrices are derived by evolution from muc will be tested via molecular biology approach. In particular, the construction of cDNA libraries from calcifying tissues of mussels and the screenings of these libraries with antibody probes will permit to isolate genes encoding for inhibiting peptides found in both mucus and skeletal matrices. The calcium-binding properties of mucus peptides will also be investigated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry inorganic compounds
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences molecular biology
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2300 RA Leiden
Netherlands
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