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Contenu archivé le 2024-06-10

Role of the ngf-induced gene pc3 in the control of neuronal cell proliferation and differentiation in vitro and in vivo

Objectif



The PC3 gene is an immediate early gene, induced in PC12 cells by treatment with nerve growth factor. It is one of the two members of a new gene family, with a putative antiproliferative function. PC3 is expressed in the developing rat neural tube with a pattern that correlates with neuronal cell birthday. PC3 is therefore hypothesized to be functionally involved either in the growth arrest of neuronal precursors and PC12 cells, or in an early phase of neuronal commitment, or both, the two processes being tightly related to each other. The aims of this project are: a) to test this hypothesis by altering PC3 expression both in PC12 cells and in neuroepithelial cells in living embryos and then evaluating the effects on both cell proliferation and neuronal differentiation; b) to investigate further the functional role of the PC3 protein by analyzing its subcellular localization and its interactions with other proteins.

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

Données non disponibles

Régime de financement

RGI - Research grants (individual fellowships)

Coordinateur

Ruprecht-Karls-Universität Heidelberg
Contribution de l’UE
Aucune donnée
Adresse
364,Im Neueunheimer Feld 364
69120 Heidelberg
Allemagne
Coût total
Aucune donnée

Participants (1)