Objective The neuron is a highly polarized cell. The morphology of a neuron is essential for its function. Little is known about the way in which neurons acquire their polarity. The specific transport and sorting of the distinct intracellular components into axons and dendrites contribute directly to the establishment of neuronal polarity. Much of this transport is made along microtubules mediated by microtubule-associated motor proteins as the kinesin superfamily. The hypothesis that our project would like to demonstrate is that during neuronal development many specific kinesins appear. These kinesins would associate with dendritic or axonal vesicles helping them to choose the right microtubules for their appropriate delivery. For our study we would use fetal rat hippocampal neurons in culture which establish axonal and dendritic arbors with a molecular organization similar to their counterparts in situ. They also have a controlled pattern of development thus providing an homogeneous source of material. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TL05 - Cell Biology Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator EUROPEAN MOLECULAR BIOLOGY LABORATORY Address Meyerhofstraße 1 69117 Heidelberg Germany See on map EU contribution € 0,00 Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Spain EU contribution € 0,00 Address See on map
