Objective
Termination of transcription defines the actual end of a gene and is mediated by signals involved in 3' end processing of the nascent RNA transcript as well as additional downstream elements. Deletion of these terrnination signals can lead to interference between adjacent genes resulting in impairment of expression of the downstream gene. This suggests a key role for termination in the regulation of gene expression. Interference has been observed in a number of genetic systems and represents a serious problem in the design of vectors for gene therapy. In the first year of my PhD, I have investigated the biological role of interference by studying the effect of placing two genes (transcribed by RNA polymerase II) in close proximity in a chromosomal context. Using such constructions I have studied the molecular basis of this mechanism by directly characterising the effect of interference on the binding of transcription factors to the downstream positioned gene.
I now intend to define more completely the general significance of this mechanism in genetically tractable yeast systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics RNA
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 3RE OXFORD
United Kingdom
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