Skip to main content
Weiter zur Homepage der Europäischen Kommission (öffnet in neuem Fenster)
Deutsch de
CORDIS - Forschungsergebnisse der EU
CORDIS
Inhalt archiviert am 2024-04-30

T i between rnap ii prom

Ziel



Termination of transcription defines the actual end of a gene and is mediated by signals involved in 3' end processing of the nascent RNA transcript as well as additional downstream elements. Deletion of these terrnination signals can lead to interference between adjacent genes resulting in impairment of expression of the downstream gene. This suggests a key role for termination in the regulation of gene expression. Interference has been observed in a number of genetic systems and represents a serious problem in the design of vectors for gene therapy. In the first year of my PhD, I have investigated the biological role of interference by studying the effect of placing two genes (transcribed by RNA polymerase II) in close proximity in a chromosomal context. Using such constructions I have studied the molecular basis of this mechanism by directly characterising the effect of interference on the binding of transcription factors to the downstream positioned gene.
I now intend to define more completely the general significance of this mechanism in genetically tractable yeast systems.

Wissenschaftliches Gebiet (EuroSciVoc)

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

Daten nicht verfügbar

Finanzierungsplan

RGI - Research grants (individual fellowships)

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
EU-Beitrag
Keine Daten
Adresse
SOUTH PARKS ROAD
OX1 3RE OXFORD
Vereinigtes Königreich
Gesamtkosten
Keine Daten

Beteiligte (1)