Objective Recent advances in microbiology and force measurement techniques allow to perform quantitative mechanical experiments on single biomolecules. In this project, I will investigate the elementary processes of adhesion, at the level of a single molecule of DNA. I envisage a series of quantitative force measurements under conditions controlled to the molecular level. A typical experimental configuration will consist of a single DNA molecule attached by one end to a solid surface and by the other end to a microscopic bead. The latter is fixed to a soft micro-needle and forces are directly measured by a microscopic imaging of the bead. I will study the interaction between the molecule and a solid surface as well as some specific interactions within the biomolecule itself. The experiments, which will be prepared in close collaboration with biologists, are interesting from a physical, biological and applied point of view. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesbiological sciencesmicrobiology Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TP12 - Condensed Matter - Soft Matter and Polymer Physics Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator Centre National de la Recherche Scientifique Address 24,rue lhomond 75005 Paris France See on map EU contribution € 0,00 Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Germany EU contribution € 0,00 Address See on map
