Objectif Recent advances in microbiology and force measurement techniques allow to perform quantitative mechanical experiments on single biomolecules. In this project, I will investigate the elementary processes of adhesion, at the level of a single molecule of DNA. I envisage a series of quantitative force measurements under conditions controlled to the molecular level. A typical experimental configuration will consist of a single DNA molecule attached by one end to a solid surface and by the other end to a microscopic bead. The latter is fixed to a soft micro-needle and forces are directly measured by a microscopic imaging of the bead. I will study the interaction between the molecule and a solid surface as well as some specific interactions within the biomolecule itself. The experiments, which will be prepared in close collaboration with biologists, are interesting from a physical, biological and applied point of view. Champ scientifique sciences naturellessciences biologiquesgénétiqueADNsciences naturellessciences biologiquesbiochimiebiomoléculesciences naturellessciences biologiquesmicrobiologie Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Thème(s) 0302 - Post-doctoral research training grants TP12 - Condensed Matter - Soft Matter and Polymer Physics Appel à propositions Data not available Régime de financement RGI - Research grants (individual fellowships) Coordinateur Centre National de la Recherche Scientifique Adresse 24,rue lhomond 75005 Paris France Voir sur la carte Contribution de l’UE Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Not available Allemagne Contribution de l’UE € 0,00 Adresse Voir sur la carte Autres sources de financement Aucune donnée
