Objective
The bacteria Bartonellaceae are considered as emerging pathogens, having recently been recognised as the agents of a variety of infections. Profound manifestations are encountered among AIDS patients and the inner city homeless, and if untreated, can be life-threatening.
As Bartonella infections manifest as a wide range of non-specific presentations, microbiological diagnosis is necessary.
The fastidious nature of these organisms limits the usefulness of axenic media in obtaining isolates, and thus molecular biological methods are now being developed for diagnosis.
The aims of this study are: [1] to gain experience with, and apply, specialized cultivation techniques used for isolation of obligate intracellular baxcteria, to the isolation of Bartonella; [2] to combine electron microscopy with in situ hybridisation techniques incorporating Bartonella-specific oligonucleotide probes to provide a specific and sensitive method of visualising the organism in infected tissues; [3] to develop PCR-based methods for detecting, identifying and differentating uncultured Bartonella species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences health sciences infectious diseases RNA viruses HIV
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
13385 MARSEILLE
France
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