Objective
Vasopressin (VP) and oxytocin (OT) have a variety of physiological effects on the nervous system. Several of these central effects result in modulation of processes that underlie memory functions. VP is considered as a memory-enhancing agent, while OT can inhibit memory processes. In the brain the Vla and OT receptors have been demonstrated and thought to be responsible for the central effects of VP and OT and their analogs. However, two lines of observations prompt to revision of this assumption, and urge molecular studies on the expression, regulation and function of the VP and OT receptors in the brain.
Firstly, endogenous metabolites of VP and OT have very potent effects on the brain involving a distinct receptor of unknown identity. Secondly, the abundant expression of the Vlb receptor in the rodent has been a surprise in the field. These finding have major implications for the development and application of analogs of VP and OT of therapeutic purposes concerning brain functions. At present time, the host laboratory is cloning and characterizating the VP and OT metabolite receptors. Consequently, the objectives of this project are:
1.- Expression and regulation of VP/OT receptors in the rodent brain, specially the Vlb and the metabolites receptors.
2.- Expression of VP/OT receptors in the human brain, in relation to pathology (e.g: memory disturbed in Alzheimer patients).
3.- If time is available, the applicant will colaborate in the characterization of the VP metabolite receptor.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine pathology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3584 CG Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.