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Contenu archivé le 2024-06-10

Potential molybdenum sequestering agents - biomolecules and synthetic analogues

Objectif



Micro-organisms excrete low-molecular weight chelators, siderophores, in response to iron deficiency. Most siderophores are hexadentate ligands which form highly stable six-coordinate complexes with iron. In contrast the bis(catecholamide) siderophore N,N-(2,3-dihydroxybenzoyl)-L-lysine of Azotobacter vinelandii, is ideally suited for binding the four vacant coordination sites of MoO2 . The aim of this proposal is to determine the chemical design features which enable bis- and triscatecholate siderophores of A. vinelandii and their analogues to discriminate between Fe(III) and Mo(VI), to study the redox behaviour of these complexes, and to determine the role they play in the siderophore-mediated transport of Mo in A. vinelandii. This study of may lead to specific sensing applications, and to a better understanding of the chemistry underlying the initial biological transformations of Mo.

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

Données non disponibles

Régime de financement

RGI - Research grants (individual fellowships)

Coordinateur

John Innes Centre
Contribution de l’UE
Aucune donnée
Adresse
Norwich Research Park Colney
NR4 7UH Norwich
Royaume-Uni
Coût total
Aucune donnée

Participants (1)