Objective
Double stranded DNA, the carrier of genetic information, is an ideal target for the treatment of cancer and viral desease. Inhibited gene expression by creating irreversible damages on DNA is now a widely use strategy.
Various nuclease chemical systems are described in literature. For example, mesotetrakis(4-N-methyl-pyridiniumyl)porphyrinato-Mn(m) is an efficient DNA cleaver[1].
We will focus our interest on modified Hoechst 33258 coupled to a metalloporphyrin[2] or on catecholate analogues of Hoechst 33258 able to chelate copper (II)[3]. In order to optimize nuclease activity of such system, investigation of interaction between these molecules and DNA is necessary.
Training content (objective, benefit and expected irnpact)
The project will involve modelling to rationnalise potential binding models of the hybrid H33258 to duplex DNA and some high field NMR studies of the complex. It may also involve fluorescence titration of the complex (including stopped-flow). I shall also be able to interact with Pr Douglas on his new DNA cleavage system, thus transferring expertise from our Toulouse laboratory.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
M13 9PL Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.