Objective
Research objectives and content
The objectives of the project are the mapping by linkage analysis and the cloning of candidate susceptibility genes affecting inherited predisposition and resistance to murine skin tumor development in two selected murine lines. Two lines of mice (sensible and resistant to carcinogens) produced by a bidirectional selective breeding and presenting squamous cell papillomas and carcinomas will be used. Markers such as simple sequence length polymorphisms (SSLPs) and strain specific interspersed repetitive-PCR (IRS-PCR) will be mapped in the parental murine strains in order to perform the linkage analysis in the F2 progeny cross. When the chromosomal location of skin tumor
predisposition/resistance loci will be established, a positional cloning of the candidate genes will be started. Contemporary to these studies, we will begin to clone, by differential dysplay PCR and RNA substraction techniques, genes differentially expressed in the normal skin of the two strains of mice.
Training content (objective, benefit and expected impact)
As a medical geneticist, I want to orientate my career in the field of the polygenic diseases for studying their genetic basis. This training will provide me the knowledge necessary to be able to perform complex genetic and linkage analysis as well as the possibility to learn essential techniques of molecular biology for cloning new genes.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer squamous cell carcinoma
- natural sciences biological sciences genetics genetic selection
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20133 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.