Objective
The molecular identification of antigens recognized by autologous cytotoxic T lymphocytes (CTL) on human tumors opens new possibilities of specific immunotherapy of cancer. Several antigens have recently been identified on human melanoma by a genetic approach. This project aims at identifying such antigens on renal cell carcinoma. A first requisite is the obtention of a CTL clone specifically directed against the autologous tumor line. To identify the antigen recognized by this CTL, a cDNA library from this tumor line will be transfered into COS cells, together with the cDNA encoding the presenting HLA molecule. Transfected COS cells will then be screened with the CTL by looking at their ability to induce TNF production by the CTL. This should allow the isolation of the cDNA encoding the antigen. This cDNA will then be sequenced and analysed by standard molecular biology techniques to define the pattern of expression of the tumor antigen and the nature of the antigenic peptide presented to the CTL.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine oncology skin cancer melanoma
- medical and health sciences basic medicine immunology immunotherapy
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1200 BRUXELLES
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.