Synthesis of several generations of dendrimers with amidometallocene/ amidometallocenium termini with various topologies and study as spectroscopyand electrochemical sensors

Project Information

Grant agreement ID: FMBI961651

Project closed

Start date 1 June 1997

End date 31 May 1999

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost € 0,00

EU contribution No data

Coordinated by

Centre National de la Recherche Scientifique (CNRS)
France

Objective

Research objectives and content
We propose to synthesize dendrimers which will be able to specifically recognize anions usign redox sensors located at the termini of the dendrimer branches. This recognition should strongly depend on the core, on the length of the dendritic segment added at each generation and on the number of dendritic generations. In order to investigate this point, several generations of dendrimers will be synthe size, functionnalized with redox centers, and tested for the recognition of the a nions. We should be able to investigate the best dendrimer for each anion in or der to recognize and optimize this process.
The recognition of the anion with the dendrimer will be effected using an amido metallocene/amidometallocenium termini using the electrostatic interaction betwe en its cationic oxidized form and the anion in synergy with the supramolecular interaction between the acidic hydrogenation of the amide function and the anion The interaction should be an order of magnitude larger with the cationic metallocenium termini than with neutral metallocene form.
This should be probed by monitoring the shift of the NH chemical shift in lH NMR when switching from an 18-electron cationic cobalticenium to the isoelectronic (18 electron) neutral ferrocene. Thus both lH NMR and electrochemical methods will be used in complementarity for anionic recognition, which will enrich the set of possibilities of sensors. The topology, surface, shape and cavities of dendrimers provide the potential for the function of drug transport and delivery to biological targets. To reach this ambitious goal, it is fires importance achieve SPECIFIC MOLECULAR RECOGNITION of molecular fragments and ions by dendrimers
Molecular rectifiers, transistors and photodiodes have envisaged, the later requiring features such as those of charge-transfer states in organic molecules, in metal complexes. The general objectives of this postdoctoral project offer exciting perspectives in the BIOTECHNOLOGY AND TECHNOLOGY FIELDS.

Fields of science

• natural sciences › chemical sciences › electrochemistry
• natural sciences › mathematics › pure mathematics › topology
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TC07 - Molecular Aspects of New Materials

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

Centre National de la Recherche Scientifique (CNRS)

• EU contribution: No data
• Address: 351 cours de la Libération ; 33405 Talence ; France
• Total cost: No data

Participants (1)

Not available

Spain

• EU contribution: No data
• Total cost: No data