Objective
This proposal is centered around Magnetic Resonance Imaging (MRI) Guided Focused Ultrasound (FUS) and two of its medical applications, tumor ablation and gene therapy. FUS has been known to be very effective to heat tissue locally. However, problems with the localization and dosimetry of | thermal dose have prevented widespread use. MRI temperature imaging combined with anatomical MRI can help to overcome | these problems. The research will be centered around the development of ultrafast noninvasive temperature imaging in vivo and the design effective FUS within the MR magnet. | Two possible applications will be further investigated: | I) Application of high intensity FUS to destroy a tumor without damaging surrounding tissue. 2) Temporal and spatial control of expression of a therapeutic gene, sensitized to heat using the Heat Shock Protein prom | Thus, high local and temporal control of gene therapy can be achieved using controlled periods of local heat elevation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- natural sciences physical sciences acoustics ultrasound
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
33076 BORDEAUX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.