Objective This proposal is centered around Magnetic Resonance Imaging (MRI) Guided Focused Ultrasound (FUS) and two of its medical applications, tumor ablation and gene therapy. FUS has been known to be very effective to heat tissue locally. However, problems with the localization and dosimetry of | thermal dose have prevented widespread use. MRI temperature imaging combined with anatomical MRI can help to overcome | these problems. The research will be centered around the development of ultrafast noninvasive temperature imaging in vivo and the design effective FUS within the MR magnet. | Two possible applications will be further investigated: | I) Application of high intensity FUS to destroy a tumor without damaging surrounding tissue. 2) Temporal and spatial control of expression of a therapeutic gene, sensitized to heat using the Heat Shock Protein prom | Thus, high local and temporal control of gene therapy can be achieved using controlled periods of local heat elevation. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingnatural sciencesphysical sciencesacousticsultrasound Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TP15 - Instrumentation and Applied Physics Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Address Rue léo-saignat 146, case 93 33076 Bordeaux France See on map EU contribution € 0,00 Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Netherlands EU contribution € 0,00 Address See on map
