Cel This proposal is centered around Magnetic Resonance Imaging (MRI) Guided Focused Ultrasound (FUS) and two of its medical applications, tumor ablation and gene therapy. FUS has been known to be very effective to heat tissue locally. However, problems with the localization and dosimetry of | thermal dose have prevented widespread use. MRI temperature imaging combined with anatomical MRI can help to overcome | these problems. The research will be centered around the development of ultrafast noninvasive temperature imaging in vivo and the design effective FUS within the MR magnet. | Two possible applications will be further investigated: | I) Application of high intensity FUS to destroy a tumor without damaging surrounding tissue. 2) Temporal and spatial control of expression of a therapeutic gene, sensitized to heat using the Heat Shock Protein prom | Thus, high local and temporal control of gene therapy can be achieved using controlled periods of local heat elevation. Dziedzina nauki medycyna i nauki o zdrowiubiotechnologia medycznainżynieria genetycznaterapia genowanauki przyrodniczenauki biologicznebiochemiabiocząsteczkibiałkainżynieria i technologiainżynieria medycznadiagnostyka obrazowaobrazowanie metodą rezonansu magnetycznegonauki przyrodniczenauki fizyczneakustykaultradźwięki Program(-y) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Temat(-y) 0302 - Post-doctoral research training grants TP15 - Instrumentation and Applied Physics Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Adres Rue léo-saignat 146, case 93 33076 Bordeaux Francja Zobacz na mapie Wkład UE Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Not available Niderlandy Wkład UE € 0,00 Adres Zobacz na mapie Środki z innych źródeł Brak danych
