Objective
Research objectives and content The Drosophila irregular chiasm C - roughest (irreC-rst) gene encodes a member of the DM-GRASP subgroup of the neural cell adhesion molecules of the immunoglobulin superfamily. The main aim of this project is to gain a better understanding of the biological function of IrreC-rst protein through identification of interacting partners. We plan to realise genetic screens in order to search for mutations second-site that enhance or suppresse mutant phenotypes using sensitized genotypes of irreC-rst gene. We expect from such screens to be able to isolate functionally interacting genes and to elucidate their hierarchy in regulatory pathways. Analysis of mosaic animals after mitotic recombination could permit to investigate the phenotype of the mutant clones in wild-type or otherwise mutant imaginal discs. Study of IrreC-rst expression in different mutant backgrounds could unravel interactions at the level of transcription. Another part of the proposal project is a genetic analysis of several truncated IrreC-rst proteins in vivo. Training content (objective, benefit and expected impact) Members of the DM-GRASP subfamily of neural cell adhesion molecules are temporally and spatially highly regulated and assumed to function as neuronal identifiers during brain development and l neuronal regeneration. So far knock-out and gain of function mutant phenotypes are only known for the IrreC-rst protein in Drosophila. They support the assumed significance of this class of proteins. The identification of the underlying molecular interactions will be helpful to understand regulatory pathways in which a member of the DM-GRASP subfamily of neural cell adhesion molecules is involved. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics mutation
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Coordinator
54006 Thessaloniki
Greece
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