Objective
Research objectives and content
Progression through the mammalian cell cycle is controlled by the tightly regulated activity of cyclin-dependent kinases (cdk's). Both positive and negative regulators of these kinases classify as oncogenes and tumor suppressor genes, respectively, and dysregulation of these activities is implicated in a variety of malignancies. The novel class of cdk inhibitors appears to negatively regulate G1 phase specific cdk's and, thereby, inhibit cell cycle progression. p21 is a cdk inhibitor specifically implicated in mediation of the DNA damage checkpoint, cellular senescence, and differentiation (for review see Harper & Elledge, 1996). Since p21's very complex mode of function is not yet understood and conflicting data on its features were published my research proposal is focused on elucidating the activity of p21 in more detail under different physiological conditions. My well characterized set of newly established monoclonal antibobies to human p21 will hopefully give new insights in target preferences and function of p21 under various conditions. Presently, my major interest is p21's regulation on the level of protein stability, since my own preliminary results demonstrate a quick turnover of the protein, which is mediated by the ubiquitin-proteasome protein degradation machinery. The post-translational regulation by altered protein stability appears to be an essential control mechanism of key cell cycle regulators.
Harper, W., and Elledge, S.,; Cdk inhibitors in development and cancer. Cur.Op.Gen.& Dev., 6: 56-64, 1996.
Training content (objective, benefit and expected impact)
Independent working conditions, a good panel of applyable methods and creative scientific discussions are basics for successful
research-standards in the Department of Cell Cycle and Cancer. I expect to produce a conclusive and contributory study on p21 resulting in a Ph.D thesis after approximately three years. The quality standard of this study will be of great importance for further applications in other laboratories.
Links with industry / industrial relevance (22)
None.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2100 KOEPENHAGEN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.