Objective
Research objectives and content Cellular adhesion has been shown to influence a wide variety of cellular processes, including migration, proliferation, differentiation and mitosis. Adhesion is mediated through a Group of transmembrane receptors, the integrins, which upon binding extracellular matrix (ECM) recruit cytoplasmic proteins to form multimolecular clusters called focal adhesions. Focal adhesions contain both structural proteins as well as proteins with enzymatic activity, and it is thought that they are involved in signal transduction pathways, apart from being implied in the attachment of the cell to ECM. Besides, it has been shown that the rho-subfamily of GTP-binding proteins controls the assembly of adhesion complexes and the actin filaments associated with them. The aim of this proposal is to identify the role played by members of the rho-subfamily in controlling integrin-dependent signal transduction pathways active during G1 phase of the cell cycle in mammals. The points to be explored are: a)Effect of focal adhesion complexes in cyclin inhibitor levels b)Effects of focal adhesion complexes in the activity of 4-PIP5K c)Adhesion dependence of receptor signalling pathways. Training content (objective, benefit and expected impact) Members of the Rho-subfamily GTPases are involved in the organization of actin cytoeskeleton and integrin complexes, being for this reason important regulators of cell movement and adhesion. Besides, these Rho-related GTPases provide an-essential signal required for G1 progression in the cell cycle. Therefore, by identifying the integrin signalling pathways and how they are controlled we hope to obtain a biochemical understanding of cell cycle and adhesion.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.