Role of rho-gtpases in adhesion-dependent signalling

Informations projet

N° de convention de subvention: FMBI972026

Date de début

Date de fin

Financé au titre de

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Coût total Aucune donnée

Contribution de l’UE Aucune donnée

Coordonné par

Aristotle University of Thessaloniki
Greece

Objectif

Research objectives and content Cellular adhesion has been shown to influence a wide variety of cellular processes, including migration, proliferation, differentiation and mitosis. Adhesion is mediated through a Group of transmembrane receptors, the integrins, which upon binding extracellular matrix (ECM) recruit cytoplasmic proteins to form multimolecular clusters called focal adhesions. Focal adhesions contain both structural proteins as well as proteins with enzymatic activity, and it is thought that they are involved in signal transduction pathways, apart from being implied in the attachment of the cell to ECM. Besides, it has been shown that the rho-subfamily of GTP-binding proteins controls the assembly of adhesion complexes and the actin filaments associated with them. The aim of this proposal is to identify the role played by members of the rho-subfamily in controlling integrin-dependent signal transduction pathways active during G1 phase of the cell cycle in mammals. The points to be explored are: a)Effect of focal adhesion complexes in cyclin inhibitor levels b)Effects of focal adhesion complexes in the activity of 4-PIP5K c)Adhesion dependence of receptor signalling pathways. Training content (objective, benefit and expected impact) Members of the Rho-subfamily GTPases are involved in the organization of actin cytoeskeleton and integrin complexes, being for this reason important regulators of cell movement and adhesion. Besides, these Rho-related GTPases provide an-essential signal required for G1 progression in the cell cycle. Therefore, by identifying the integrin signalling pathways and how they are controlled we hope to obtain a biochemical understanding of cell cycle and adhesion.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.

• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines
• sciences naturelles › sciences biologiques › zoologie › mammalogie

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Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Thème(s)

• 0302 - Post-doctoral research training grants

Appel à propositions

Data not available

Régime de financement

Data not available

Coordinateur

Aristotle University of Thessaloniki

• Contribution de l’UE: Aucune donnée
• Adresse: Analytical Chemistry Lab ; 54006 Thessaloniki ; Grèce
• Coût total: Aucune donnée