Objective
Research objectives and content
Despite the importance of gliogenesis in nervous system morphogenesis, the molecular mechanisms of glial differentiation have been poorly investigated. glide/gcm is a D. melanogaster gene expressed and required in glial cells. The project is aimed to determine the role of glide/gcm in gliogenesis and the genes regulating glide/gcm activity. To this purpose the effect of ubiquitous and cell type specific ectopic expression of glide/gcm will be tested. The definition In vivo of the minimal sequences necessary for glide/gcm activity will be obtained by rescue of the mutant phenotype via germ-line transformation. Finally I will perform a mutagenesis screen aimed to identify genes interacting genetically with glide/gcm by scoring for mutations that enhance or suppress the glide/gcm phenotype.
Training content (objective, benefit and expected impact)
The research project I propose will enable us to determine how glide/gcm induces gliogenesis and how its activity is regulated. To better understand the molecular bases of glial cell differentiation. The proposed project implies the use of different approaches in molecular biology and genetics. The possibility of carrying on the project in an institute of outstanding quality such as the IGBMC constitutes a unique opportunity to broaden my knowledge and skills in developmental biology and neurobiology and I consider that such training is fundamental for my research career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67404 ILLKIRCH GRAFFENSTADEN
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.