Objective
Research objectives and content. This project will develop efficient systems for targeted delivery of genes to cells,. It is an interdisciplinary project, combining my own expertise in cloning with expertise of my supervisors in viral infectivity and development of synthetic systems for gene delivery. The primary objective of the research project is to identify viral proteins capable of mediating nuclear delivery of DNA-containing nanoparticles for gene therapy. Individual objectives include: ? Identifying methods for efficient attachment of viral proteins onto DNA nanoparticles. ? Determine intracellular distributions of nanoparticles in cells by confocal microscopy ? Identification of viral proteins capable of promoting nuclear accumulation ? Evaluation of usefulness of these proteins in mediating transfection of cells in vitro. Training content (objective, benefit and expected impact) The Institute for Cancer Studies has a very good international reputation for gene therapy, and also in the study of viruses in oncology. There are few places in the world which combine these expertises. I expect to learn techniques of tissue culture, handling of DNA, reporter gene assays, microinjection and confocal analysis of intracellular distribution,. This should enable me afterwards to find good employment in this field, probably in Germany. Links with industry: The MRC Gene Therapy Programme has strong links with Glaxo/Wellcome, and Dr Seymour has increasingly strong links with Zeneca. (200 words not counting titles)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics microscopy confocal microscopy
- engineering and technology nanotechnology nano-materials
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
54006 Thessaloniki
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.