Objective
Research objectives and content
The objectives of the present proposal are related to the discovery and application of novel free radical chain reactions for organic synthesis. Within the last decade, the advantages of such a strategy, which include mild neutral conditions and the ability to operate in hindered environments, have come to be appreciated. Last year the group of Professor Motherwell has demostrated that intramolecular free radical ipso substitution of a suitably constituted sulfonyl substituted aromatic derivative by a second ortho substituted aryl radical represents a viable approach for biaryl and heterobiaryl coupling. These structures are often encountered in a wide variety of bioactive natural products of different structure and biosynthetic origin. The present proposal calls for apply this reaction in natural products synthesis, specialy pyrrolophenthridone alkaloids. On the other hand, the use of different radical triggers and additional tethering chains will be studied.
Training content (objective, benefit and expected impact)
It is the objective of the programme to get training in radical synthetic chemistry and in the synthesis of natural products. The group of Professor Motherwell, which has developed several such reactions in recent years, has an international reputation in this field. The research will provide training in several technical and scientific disciplines (ESR, RMN, HPLC, organic synthesis).
Links with industry / industrial relevance (22)
The host group is cooperating with the pharmaceutical industry (Zeneca Agrochemicals) on this subject and the applicant may benefit from this existing collaboration. We believe that radical chemistry may belong to drugs synthesis.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1 0AJ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.