Objective
Research objectives and content
Acute administration of drugs, such as cocaine, amphetamines and opioids, produces euphoria in humans and reward in animal models (1, 2). Repeated administration of these drugs with adequate doses, frequency, and chronicity produce significant adaptive changes in brain regions relevant to reinforcement. The dopamine D2 receptor (D2R) has been implicated in the reinforcing effects of several addictives substances and in the control of behavioural responses to opioids. The present research proposal is based on the investigation of the involvement of D2R, and particularly the long and short isoforms of this receptor in the mechanisms underlying drug addiction. As experimental approach, lines of mice with reduced (+/-) or absent (-/-) expression of D2R isoforms will be used to study these phenomena.
This research is of particular importance not only for the understanding of the involvement of D2 receptors in drug addiction, but also for its potential contribution in elucidating the molecular mechanisms leading to it.
Training content (objective, benefit and expected impact)
This project implies the use of different approaches in molecular biology, genetics and in behavioural studies. The possibility of carrying on the project in an institute of outstanding quality such as the IGBMC constitutes a unique opportunity to broaden my knowlodge and skills in neurobiology. I consider that such training is fondamental for my research carreer.
Links with industry / industrial relevance (22)
This research might lead to the development of novel treatments as well as of preventive measures for drug addiction
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics
- social sciences psychology behavioural psychology
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67404 ILLKIRCH GRAFFENSTADEN
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.