Molecular bases of programmed cell death in dictyostelium

Informations projet

N° de convention de subvention: FMBI972551

Projet clôturé

Date de début 1 Mars 1998

Date de fin 29 Février 2000

Financé au titre de

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Coût total Aucune donnée

Contribution de l’UE Aucune donnée

Coordonné par

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France

Objectif

Research objectives and content
Programmed Cell Death (PCD) is crucial to animal development and tissue homeostasis. Several diseases involve dysregulation of PCD. Genes controlling PCD in vertebrates, nematodes and Drosophila have been isolated. The slime mould Dictyostelium represents the earliest known occurrence in eukaryotic evolution of PCD in multicellular development. Cells secrete DIF that contributes to induce part of the population to differentiate into dead stalk cells, supporting viablc spores. Certain PCD phenomena of stalk cell formation are similar to those in higher eukaryotes. This project will i.use genetic tractability of Dictyostelium to identify genes encoding molecules required for Dictyostelium PCD, ii. establish the precise function of these genes, and iii. investigate whether homologs of these genes have similar functions in higher eukaryotes. Training content (objective, benefit and expected impact) I will learn to apply, together with usual molecular biology techniques, a variety of up-to-date techniques such as tagged mutagenesis, confocal scanning laser microscopy, cell fractionation and enzyme assays, to identify and characterize genes and their cognate proteins involved in signal transduction and execution of PCD. The training allows me to pursue a career in fundamental or applied research, for example in the fields of developmental biology, cancer or AIDS.
Links with industry / industrial relevance (22)

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.

• sciences naturelles › sciences biologiques › biologie du développement
• sciences naturelles › sciences physiques › optique › microscopie
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines › enzyme
• sciences naturelles › sciences physiques › optique › physique des lasers
• sciences naturelles › sciences biologiques › biologie moléculaire

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Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Thème(s)

• 0302 - Post-doctoral research training grants
• TL06 - Developmental Biology

Appel à propositions

Data not available

Régime de financement

RGI - Research grants (individual fellowships)

Coordinateur

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

• Contribution de l’UE: Aucune donnée
• Adresse: Parc Scientifique et Technologique de Luminy ; 13288 MARSEILLE ; France
• Coût total: Aucune donnée

Participants (1)

Not available

Pays-Bas

• Contribution de l’UE: Aucune donnée
• Coût total: Aucune donnée