Objective
Research objectives and content
- Study of the human Uncotll)lillg Protein-2 gene to determine the organisation of the gene, its possible polymorphism and its relationship with diseases related to the energy metabolism as diabetes, obesity, etc. - Analysis of the biological roles of the Uncoupling Protein-2 on the Resting Metabolic Rate, its relation to the effects in energy metabolism action of several hormones as thyroid hormones. - Study of the possible role of the Uncoupling Protein-2, which is also expressed in macrophages, spleen, thymus and lymphocytes, in the mechanism of inflamation immunity and the production of fever. -Search of other components of the family of Uncoupling Proteins, based on the cloning of a murine uncoupling protein mostly expressed in skeletal muscles Study of its capacity to uncouple respiration.
Training content (objective, benefit and expected impact)
This project will provide the applicant with background expertise to work with molecular biology techniques that constitute the basic step in the development of the work Several techniques involving gene cloning, sequencing, Southern, Northern and immmuno-blotting, plasmid construction and transient transfection of adypocite-derivated cell lines experiments, will be used as global approach to the study of gene organisation and function. The majority of these techlliqlles are in routine operation within the host institution (Centre de Recherche sur l'Endocrinologie Moleculaire et le Developpement), therefore the applicant should obtain definitive results within the postdoctoral stay.
Links witll indllstry / industrial relevance (22)
The relation of Uncoupling Protein-2 with the resting metabolic rate as well as the diet induced thermogenesis strongly suggests that it may be target for new obesity-therapy compounds Major pharmaceutical companies should be interested in research on UCP2 and other UCP homologues.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences health sciences nutrition obesity
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
92190 Meudon
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.