Hedgehog pathway and the development of the retina in xenopus laevis

Project Information

Grant agreement ID: FMBI983035

Project closed

Start date 6 June 1998

End date 5 June 2000

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

University of Cambridge
United Kingdom

Objective

Research objectives and content
Hedgehog pathway plays an essential role in differentiation of neural cells in Drosophila eye. The aim of this study is to provide further understanding in the role of this pathway in vertebrate retinogenesis. I will study where the members of this pathway are expressed in the retina, and will use a functional approach to address their function in the differentiation of retinal cells, using RNAIDNA injections, in vivo lipofections and eyebud cultures. I will also study the relationships between these genes using misexpression experiments.
Training content (objective, benefit and expected impact)
The study of the Hedgehog pathway in retina should provide new insights into the molecular basis of signaling in eye development. This training will give me the opportunity to work on Xenopus retina, an excellent model for neuro- developmental biologists, and to learn new techniques in embryology. Furthermore, since the University of Cambridge is a world renown institution, I will have the opportunity to meet and work with several world renown laboratories.
Links with industry / industrial relevance (22)
This project has no direct industrial links although the Hedgehog pathway might be involved in tumorigenesis. This project should thus be helpful for cancer related research to better understand the link between this pathway and tumorigenesis.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › clinical medicine › ophthalmology
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › clinical medicine › embryology

You need to log in or register to use this function

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TL06 - Developmental Biology

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

University of Cambridge

• EU contribution: No data
• Address: Downing Street ; CB2 3DY Cambridge ; United Kingdom
• Total cost: No data