Objective
Research objectives and content
Deficiencies in myelin lead to grave disorders in the nervous system. It was observed that variations in transterrin (Tf) gene expression in oligodendrocytes of the central nervous system (CNS) may have important consequences in myelination process. The aim of the work is to understand the mechanisms responsible for the Tf tissue-specific expression in the CNS, as well as to understand the Tf role in the CNS development, particularly in oligodendrocytes development and in its influence on myelin synthesis. For this purpose, ex vivo analysis of Tf gene expression will be performed with oligodendroglial cell lines in presence or absence of various physiological effectors and using culture conditions described for the induction of oligofrndroglial l differenciation. In addition, analysis of Tf gene expression will be studied in vivo in the CNS of transgenic mice overexpressing human Tf. The expression of some proteins markers of myelin will be also analyzed in cultured oligodendrocytes as well as in transgenic animals. Obtention and analysis of transgenic animals, cell cultures, RT-PCR, transient expression experiments in l cultured cells, in situ hybridization studies and DNA-protein interaction analysis will be the methods used.
Training content (objective, benefit and expected impact)
To obtain a PhD. in University Paris Vl in France. The thesis work will give me the necessary tools to continue my scienitic carrier under the best conditions.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.