Objective
Research objectives and content
The hypolipidemic effects of fibrates have been shown to be mediated by members of the Peroxisome Proliferator- Activated Receptor (PPAR) transcription factor family. Recently, PPARs have been implicated in the atherosclerotic processes at the vascular wall. The objective of the proposed project is to identify additional, novel nuclear receptors, which are expressed in cells of the vascular wall and therefore potentially related to atherosclerosis. In a second time, studies will be undertaken to characterize the target genes of thus identified nuclear receptors in the different cells of the vascular wall. Identification of such receptors and insight in the regulation of, amongst others, cytokines, adhesion molecules and extracellular matrix proteins may lead new pharmacological tools to direct processes away from atherosclerosis.
Training content (objective, benefit and expected impact)
The applicant will benefit from the excellent scientific and technical knowledge of an important European research group in the field of atherosclerosis and lipid metabolism. She will have the opportunity to complete her training in biochemistry by learning different molecular biology techniques. Such additional formation, in addition to the experience of working in a foreign laboratory, will allow her to develop a career in the international scientific community.
Links with industry / industrial relevance (22)
Novel nuclear receptors involved in atherogenic processes at the vascular wall may open new avenues for the development of pharmacological tools against atherosclerosis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
59019 Lille
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.