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Content archived on 2024-04-30

Tap - a gene involved in neuronal differentiation


Research objectives and content The aim of my project is to understand the role of the tap gene in the control of neuronal connectivity in Drosophila. tap encodes a transcriptional factor with a bHLH motif which is expressed at a late stage in one of the neurons that innervate each gustatory organ. As these organs are functionally different, I believe that tap is responsible for the neuronal properties of the neuron in which it is expressed. To determine the developmental function of tap, I plan to identify loss- and gain-of-function tapmutants, and to analyse their phenotypes. This will be done by using genetic (Gal4-UAS system, FRT-FLP system, transgenic lines) as well as molecular techniques (DNA constructs) combined with DiI labelling of neurons and behavioural tests. I think that a better understanding of how tap acts will help us to understand how neuronal specificity is genetically controlled. Training content (objective, benefit and expected impact) My objective is to reach a PhD level for which I have voluntarily stopped my career as a scientific journalist. I have especially chosen the team of Dr. Alain Ghysen in Montpellier, for its particularly interesting scientific l and teaching qualities, which I think will greatly improve my capabilities in dealing with difficult scientific questions. Links with industry / industrial relevance (22)

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Institut National de la Santé et de la Recherche Médicale
EU contribution
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Place Eugène Bataillon
34095 Montpellier

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