Objective We will utilise the genetic, developmental, and cytological advantages of genetics, cell and developmental biology, with biochemistry. It thereby Drosophila to study the centrosome cycle and cytokinesis, both of which closely resemble analogous processes in mammalian cells. Mitotic entry provides an ideal training ground for a multidisciplinary approach to a fundamental biological problem. The collaborating laboratories each have requires the P34 kinase activated by cdc25. We will study the roles of two genes that we have identified that regulate a Drosophila cdc25 homologue, skills that span these experimental disciplines, although having some degree of specialisation so that collectively they can provide all of the one of which appears to affect centrosome behaviour. We will characterise mutations in the two Drosophila genes for gama-tubulin and identify genes necessary expertise and training to the proposed postdoctoral workers encoding proteins that interact with gama-tubulin within the centrosome.Centrosome separation and spindle formation will be studied with reference to the phosphorylation- cycles of kinesin-like proteins and other centrosomal components by the polo kinase and protein phosphatase 2A. We will characterise several genes essential for cytokinesis, and study their interactions with reference to the localisation and phosphorylation of the gene products. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesdevelopmental biologynatural sciencesbiological sciencesgeneticsmutation Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 01 - NETWORKS Call for proposal Data not available Funding Scheme Data not available Coordinator Universidade do Porto Address 823,rua do campo allegre 4100 Porto Portugal See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 0,00 Address Universidad autonoma de madrid, cantoblanco 28049 Madrid See on map Consiglio Nazionale delle Ricerche (CNR) Italy EU contribution € 0,00 Address Città universitaria piazzale aldo moro 5 00185 Roma See on map European Molecular Biology Laboratory (EMBL) Germany EU contribution € 0,00 Address Meyerhofstraße 1 69117 Heidelberg See on map University of Cambridge United Kingdom EU contribution € 0,00 Address Downing street CB2 3EH Cambridge See on map University of Edinburgh United Kingdom EU contribution € 0,00 Address George square EH8 9XD Edinburgh See on map
