Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-05-14

Relating mitotic control to the mechanics of cell division

Obiettivo



We will utilise the genetic, developmental, and cytological advantages of genetics, cell and developmental biology, with biochemistry. It thereby Drosophila to study the centrosome cycle and cytokinesis, both of which closely resemble analogous processes in mammalian cells. Mitotic entry provides an ideal training ground for a multidisciplinary approach to a fundamental biological problem. The collaborating laboratories each have requires the P34 kinase activated by cdc25. We will study the roles of two genes that we have identified that regulate a Drosophila cdc25 homologue, skills that span these experimental disciplines, although having some degree of specialisation so that collectively they can provide all of the one of which appears to affect centrosome behaviour. We will characterise mutations in the two Drosophila genes for gama-tubulin and identify genes necessary expertise and training to the proposed postdoctoral workers encoding proteins that interact with gama-tubulin within the centrosome.

Centrosome separation and spindle formation will be studied with reference to the phosphorylation- cycles of kinesin-like proteins and other centrosomal components by the polo kinase and protein phosphatase 2A. We will characterise several genes essential for cytokinesis, and study their interactions with reference to the localisation and phosphorylation of the gene products.

Campo scientifico (EuroSciVoc)

Programma(i)

Argomento(i)

Invito a presentare proposte

Dati non disponibili

Meccanismo di finanziamento

Dati non disponibili

Coordinatore

Universidade do Porto
Contributo UE
Nessun dato
Indirizzo
823,Rua do Campo Allegre
4100 Porto
Portogallo
Costo totale
Nessun dato

Partecipanti (5)