Objective Each team will train a young post-doctoral fellow from an EC member state. major histocompatibility complex (MHC) with peptides derived from protein Importantly, the post docs will integrate into the training programs of the antigens. Therefore, the objective of the project is to unravel the home institutes, and work in selected laboratories of network partners for additional expertise. Additional important measures are annual meetings mechanism leading to peptide loading of MHC class I and class II (2-3 days) attended by all young researchers in the network, and mutual molecules. Part of the project became possible through the recent pioneering discovery by J. Trowsdale and other laboratories that the MHC short-term visits of researchers. encodes a novel set of genes that are crucial for antigen presentation, namely the TAP peptide transporters, proteasome subunits, and HLA-DM. Thus, for MHC class I presentation a major focus will be to understand the specificity and mechanism of the TAP transporters and their associated components. This work will have implications far beyond immunology as the transport mechanism of the large family of ABC transporters (including the multi-drug resistance transporter) is totally unknown. For MHC class II presentation the role of the newly discovered HLA-DM molecule will be a major goal as well as the structure of the MHC class II/Invariant chain (Ii) complex from which Ii has to be removed prior to peptide loading, and, importantly, the intracellular transport of class II molecules and identification of endosomal sub compartments where peptide loading takes place. With these efforts it will be possible to provide a fairly complete picture of the intracellular events important for antigen presentation. The results obtained will be important to devise strategies for vaccination and intervention in cancer, auto immune disorders and allergy. The network partners have all participated the work leading up to this project, a project which is based on already preexisting, fruitful collaborations between various network partners. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncologymedical and health sciencesclinical medicineallergologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 01 - NETWORKS Call for proposal Data not available Funding Scheme NET - Research network contracts Coordinator University of Oslo EU contribution No data Address 316 Oslo-Blindern Norway See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Parc Scientifique et Technologique de Luminy 13288 MARSEILLE See on map Total cost No data Consiglio Nazionale delle Ricerche (CNR) Italy EU contribution No data Address Via Toiano 6 80072 Arco Felice Napoli See on map Total cost No data Imperial Cancer Research Fund (ICRF) United Kingdom EU contribution No data Address 44 Lincoln's Inn Fields WC2A 3PX London See on map Total cost No data Stiftung Deutsches Krebsforschungszentrum Germany EU contribution No data Address 280,Im Neuenheimer Feld 69009 Heidelberg See on map Total cost No data THE NETHERLANDS CANCER INSTITUTE / ANTONI VAN LEEUWENHOEK HOSPITAL Netherlands EU contribution No data Address 121,Plesmanlaan 121 1066 CX AMSTERDAM See on map Total cost No data
