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REGULATION OF APOPTOSIS in TISSUE HOMEOSTASIS AND CANCER : ROLE OF TNF-R1 AND Fas/APO-1

Objective



Recent evidence suggests that not only unrestricted cell proliferation but 1. Each of the young postdocs is supposed to be educated for at least 3 also the inability to undergo apoptosis in response to physiological months in at least one of the other collaborating groups.
signals contributes to diseases such as autoimmunity or cancer. Aim of the It is also planned to exchange personnel in such a way that
experiments are performed in the most adequate laboratory where project is the definition of the molecular requirements for the generation a certain technique is routinely performed, e.g. a biochemical and intracellular transmission of the apoptotic signal from surface assay or construction and production of retroviral gene transfer vectors. receptors. The model we are using is represented by two highly related receptors, the tumor necrosis factor type 1 (TNF-R1) and the Fas/APO-l 3. Each spring a course is to be held to help distributing important receptor. Cross-linking of TNF-R1 and Fas/APO-l by their specific ligands technologies and knowledge from within the network. This course is also supposed to be open to other members of the network laboratories triggers a cascade of still largely undefined events leading to apoptosis. such as graduate and undergraduate students.
In detail, we will address the following:
1. the function of death-domain containing proteins in signaling. 4. Each autumn a meeting is to be held in one of the participating autumn a meeting is to be held in one of the participating countries. The 2. signal transduction (phospholipid messengers, MAP kinase cascade. young postdocs and the graduate students are expected to join these 3. role of gatekeeping molecules (p53 and the bcl-2 family)
meetings.
4. role of downstream effectors (ICE/CASP-Proteases)
Defining the molecular steps responsible for TNF-R1 and Fas/APO-I-induced 5. An exchange program for graduate students will be established. apoptosis will reveal potential therapeutic targets to circumvent This should increase mobility and facilitate introduction of new anti-apoptotic strategies adopted by cancer cells to survive. To uncover techniques.
such strategies has potential relevance for both diagnosis and selective therapy not only of tumors but also autoimmune disease.

Funding Scheme

NET - Research network contracts

Coordinator

Humboldt-Universität zu Berlin
Address
80,Lindberger Weg
13125 Berlin
Germany

Participants (7)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Parc Scientifique Et Technologique De Luminy
13288 Marseille
Centre National de la Recherche Scientifique
France
Address

92265 Fontenay Aux Roses
Consiglio Nazionale delle Ricerche (CNR)
Italy
Address
Viale Marx 43
00137 Roma
Eberhard-Karls-Universität Tübingen
Germany
Address
10,Otfried Müller Strasse
72074 Tübingen
FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Belgium
Address
35,Ledeganckstraat 35
9000 Gent
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
College Green
4 Dublin
UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA
Italy
Address
Via Di Tor Vergata 135
00133 Roma