Tissue engineered bone formation, substitution and regeneration: application of porous calcium phosphate scaffold materials and growth factors.

Objective

The demand for Bone Graft Materials (BGM) has been increasing steadily in recent years particularly in orthopedic, dental, maxillo-facial and neurosurgery where there is a need to replace missing bone and enhance bone formation. Currently, bone autograft is the golden standard. Due to limited amounts it can only be used in cases of small defects. The harvesting procedure poses substantial risks for long term pain and discomfort with a risk of infection and nerve lesion. Alternatives such as bone alllografts are associated with risks of transferring blood borne diseases, e.g. HIV and various kinds of hepatitis. There are also problems with donor matching, storage and high costs of manufacturing. In the light of these factors, the use of Synthetic Bone Graft Materials (SBGM) is very attractive. There is particular interest in developing engineered SBGM which can be used as scaffolds for seeding cells and transplanted back in the body. This can enhance fixation and integration of the implant by encouraging bone in-growth and provide a viable alternative for load-bearing and non load-bearing osseous defects such as joints and maxillo-facial reconstruction.

Fields of science

• natural sciences › chemical sciences › inorganic chemistry › alkaline earth metals
• medical and health sciences › health sciences › infectious diseases › RNA viruses › HIV
• medical and health sciences › medical biotechnology › implants › artificial bone

Programme(s)

• FP5-GROWTH - Programme for research technological development and demonstration on "Competitive and sustainable growth 1998-2002"

Topic(s)

• 1.1.3.-5. - RTD Activities of a Generic Nature : materials and their technologies for production and transformation and new and improved materials and production technologies in the steel field

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

DANISH TECHNOLOGICAL INSTITUTE

Address

Gregersensvej
2630 Taastrup
Denmark

Participants (7)

FIN- CERAMICA FAENZA SRL

Italy

Address

Via Granarolo 102
48018 Faenza

HI-POR CERAMICS LIMITED

United Kingdom

Address

C/o Dytech Corporation Ltd Stubley Lane
S18 1LS Sheffield

INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE

France

Address

Rue Des 36 Ponts, 38
31400 Toulouse

INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO

Italy

Address

Viale Benedetto Xv 10
16132 Genova

ORTHOPEDIE BIOMECANIQUE LOCOMOTION

France

Address

Avenus De La République 127
92120 Montrouge

QUEEN MARY AND WESTFIELD COLLEGE - UNIVERSITY OF LONDON

United Kingdom

Address

Brockey Hill, Stanmore
HA7 4LP Stanmore

SKEJBY HOSPITAL - AARHUS UNIVERSITY HOSPITAL

Denmark

Address

Brendstrupgaardsvej
8200 Aarhus C