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Tissue engineered bone formation, substitution and regeneration: application of porous calcium phosphate scaffold materials and growth factors.

Objective

The demand for Bone Graft Materials (BGM) has been increasing steadily in recent years particularly in orthopedic, dental, maxillo-facial and neurosurgery where there is a need to replace missing bone and enhance bone formation. Currently, bone autograft is the golden standard. Due to limited amounts it can only be used in cases of small defects. The harvesting procedure poses substantial risks for long term pain and discomfort with a risk of infection and nerve lesion. Alternatives such as bone alllografts are associated with risks of transferring blood borne diseases, e.g. HIV and various kinds of hepatitis. There are also problems with donor matching, storage and high costs of manufacturing. In the light of these factors, the use of Synthetic Bone Graft Materials (SBGM) is very attractive. There is particular interest in developing engineered SBGM which can be used as scaffolds for seeding cells and transplanted back in the body. This can enhance fixation and integration of the implant by encouraging bone in-growth and provide a viable alternative for load-bearing and non load-bearing osseous defects such as joints and maxillo-facial reconstruction.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

DANISH TECHNOLOGICAL INSTITUTE
Address
Gregersensvej
2630 Taastrup
Denmark

Participants (7)

FIN- CERAMICA FAENZA SRL
Italy
Address
Via Granarolo 102
48018 Faenza
HI-POR CERAMICS LIMITED
United Kingdom
Address
C/o Dytech Corporation Ltd Stubley Lane
S18 1LS Sheffield
INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE
France
Address
Rue Des 36 Ponts, 38
31400 Toulouse
INSTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
Italy
Address
Viale Benedetto Xv 10
16132 Genova
ORTHOPEDIE BIOMECANIQUE LOCOMOTION
France
Address
Avenus De La République 127
92120 Montrouge
QUEEN MARY AND WESTFIELD COLLEGE - UNIVERSITY OF LONDON
United Kingdom
Address
Brockey Hill, Stanmore
HA7 4LP Stanmore
SKEJBY HOSPITAL - AARHUS UNIVERSITY HOSPITAL
Denmark
Address
Brendstrupgaardsvej
8200 Aarhus C