Objective Catheter-associated infections are a major problem in modern medicine and one of the most common causes of death in the treatment of seriously ill patients. The proposed project is focused to the prevention of bacterial colonization on peritoneal dialysis catheters by a biomimetic monomolecular coating consisting of tetraetherlipid (TEL) molecules. The TEL molecules will be immobilised covalently resulting in a dense and stable membrane-like barrier against bacterial adhesion and biofilm formation. Due to the fact that bacterial adherence is controlled thermodynamically the outermost hydrophilic headgroup of the TEL will be modified to obtain a positive enthalpy of adhesion and to allow surface-coupling of antimicrobial agents. Thus anti-adhesive and an anti-microbial catheter surfaces can be designed to prevent bacterial adhesion as the main prerequisite for medical device related infections. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologyengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesclinical medicinenephrologyrenal dialysis Programme(s) FP5-GROWTH - Programme for research technological development and demonstration on "Competitive and sustainable growth 1998-2002" Topic(s) 1.1.3.-5. - RTD Activities of a Generic Nature : materials and their technologies for production and transformation and new and improved materials and production technologies in the steel field Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUTE FOR BIOPROCESS AND ANALYTICAL MEASUREMENT TECHNIQUES E.V. EU contribution No data Address Rosenhof 37308 HEILBAD HEILIGENSTADT Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all BMP LABOR FUER MEDIZINISCHE MATERIALPRUEFUNG GMBH Germany EU contribution No data Address Pauwelsstrasse 19 52074 AACHEN See on map Total cost No data FOUNDATION FOR TECHNICAL AND INDUSTRIAL RESEARCH AT THE NORWEGIAN INSTITUTE OF TECHNOLOGY Norway EU contribution No data Address Sem Saelandv 2A 7465 TRONDHEIM See on map Total cost No data HUMECA B.V. Netherlands EU contribution No data Address Het Bijvank 251-A 7544 DB ENSCHEDE See on map Total cost No data MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG Germany EU contribution No data Address Hollystrasse 1 06097 HALLE (SAALE) See on map Total cost No data R.I.L.A.B. SRL - RESEARCH AND INFORMATIC FOR THE ENVIRONMENTAL AND BIOMEDICAL LABORATORY Italy EU contribution No data Address Via Guerrazzi 24/12 B 16146 GENOVA See on map Total cost No data UNIVERSITY OF GENOVA Italy EU contribution No data Address Via Opera Pia 13 16145 GENOVA See on map Total cost No data
