Biocompatible surfaces to minimise medical device associated infections

Project Information

ADHESTOP

Grant agreement ID: G5RD-CT-2001-00594

Project closed

Start date 1 December 2001

End date 31 May 2005

Funded under

• Programme for research technological development and demonstration on "Competitive and sustainable growth 1998-2002"

Total cost € 1 688 577,00

EU contribution € 1 134 732,00

Coordinated by

INSTITUTE FOR BIOPROCESS AND ANALYTICAL MEASUREMENT TECHNIQUES E.V.
Germany

Objective

Catheter-associated infections are a major problem in modern medicine and one of the most common causes of death in the treatment of seriously ill patients. The proposed project is focused to the prevention of bacterial colonization on peritoneal dialysis catheters by a biomimetic monomolecular coating consisting of tetraetherlipid (TEL) molecules. The TEL molecules will be immobilised covalently resulting in a dense and stable membrane-like barrier against bacterial adhesion and biofilm formation. Due to the fact that bacterial adherence is controlled thermodynamically the outermost hydrophilic headgroup of the TEL will be modified to obtain a positive enthalpy of adhesion and to allow surface-coupling of antimicrobial agents. Thus anti-adhesive and an anti-microbial catheter surfaces can be designed to prevent bacterial adhesion as the main prerequisite for medical device related infections.

Fields of science

• engineering and technology › materials engineering › coating and films
• medical and health sciences › clinical medicine › nephrology › renal dialysis

Programme(s)

• FP5-GROWTH - Programme for research technological development and demonstration on "Competitive and sustainable growth 1998-2002"

Topic(s)

• 1.1.3.-5. - RTD Activities of a Generic Nature : materials and their technologies for production and transformation and new and improved materials and production technologies in the steel field

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE FOR BIOPROCESS AND ANALYTICAL MEASUREMENT TECHNIQUES E.V.

• EU contribution: No data
• Address: Rosenhof ; 37308 HEILBAD HEILIGENSTADT ; Germany
• Total cost: No data

Participants (6)

BMP LABOR FUER MEDIZINISCHE MATERIALPRUEFUNG GMBH

Germany

• EU contribution: No data
• Address: Pauwelsstrasse 19 ; 52074 AACHEN
• Total cost: No data

FOUNDATION FOR TECHNICAL AND INDUSTRIAL RESEARCH AT THE NORWEGIAN INSTITUTE OF TECHNOLOGY

Norway

• EU contribution: No data
• Address: Sem Saelandv 2A ; 7465 TRONDHEIM
• Total cost: No data

HUMECA B.V.

Netherlands

• EU contribution: No data
• Address: Het Bijvank 251-A ; 7544 DB ENSCHEDE
• Total cost: No data

MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

Germany

• EU contribution: No data
• Address: Hollystrasse 1 ; 06097 HALLE (SAALE)
• Total cost: No data

R.I.L.A.B. SRL - RESEARCH AND INFORMATIC FOR THE ENVIRONMENTAL AND BIOMEDICAL LABORATORY

Italy

• EU contribution: No data
• Address: Via Guerrazzi 24/12 B ; 16146 GENOVA
• Total cost: No data

UNIVERSITY OF GENOVA

Italy

• EU contribution: No data
• Address: Via Opera Pia 13 ; 16145 GENOVA
• Total cost: No data