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Biocompatible surfaces to minimise medical device associated infections

Objective

Catheter-associated infections are a major problem in modern medicine and one of the most common causes of death in the treatment of seriously ill patients. The proposed project is focused to the prevention of bacterial colonization on peritoneal dialysis catheters by a biomimetic monomolecular coating consisting of tetraetherlipid (TEL) molecules. The TEL molecules will be immobilised covalently resulting in a dense and stable membrane-like barrier against bacterial adhesion and biofilm formation. Due to the fact that bacterial adherence is controlled thermodynamically the outermost hydrophilic headgroup of the TEL will be modified to obtain a positive enthalpy of adhesion and to allow surface-coupling of antimicrobial agents. Thus anti-adhesive and an anti-microbial catheter surfaces can be designed to prevent bacterial adhesion as the main prerequisite for medical device related infections.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTE FOR BIOPROCESS AND ANALYTICAL MEASUREMENT TECHNIQUES E.V.
Address
Rosenhof
37308 Heilbad Heiligenstadt
Germany

Participants (6)

BMP LABOR FUER MEDIZINISCHE MATERIALPRUEFUNG GMBH
Germany
Address
Pauwelsstrasse 19
52074 Aachen
FOUNDATION FOR TECHNICAL AND INDUSTRIAL RESEARCH AT THE NORWEGIAN INSTITUTE OF TECHNOLOGY
Norway
Address
Sem Saelandv 2A
7465 Trondheim
HUMECA B.V.
Netherlands
Address
Het Bijvank 251-A
7544 DB Enschede
MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG
Germany
Address
Hollystrasse 1
06097 Halle (Saale)
R.I.L.A.B. SRL - RESEARCH AND INFORMATIC FOR THE ENVIRONMENTAL AND BIOMEDICAL LABORATORY
Italy
Address
Via Guerrazzi 24/12 B
16146 Genova
UNIVERSITY OF GENOVA
Italy
Address
Via Opera Pia 13
16145 Genova