Objective
The present research project was focused on the study of the molecular basis (DNA analysis ) of the response to antidepressant treatments in Mood Disorders. We studied different responses of patients treated with serotonin reuptake inhibitors (SSRls ) that are the most used antidepressant drugs for their efficacy and relatively favourable side effect profile compared to trycicJic antidepressants (Masand and Gupta, 1999; SchIoss and Williams, 1998). The possible definition of a genetic liability profile for drugs side effects and efficacy could be of great help in treatments that need weeks to months to be effective Up to now few clinical features are available for an early recognition of responders and this is absolutely insufficient. Converging evidences suggest that genetic predisposition plays an important role in antidepressant response. During the last years, the Research Unit of Mood Disorders ofS. Raffaele Hospital in Milan (where this studied was performed) has reached a very high scientific results in the field of pharmacogenomics. In particular, the efficacy and time of onset of SSRls have been associated with a polymorphism in the promoter region of the serotonin transporter gene (5-HTTPR), that is a prime target of SSRIs, by many independent studies; at the same time, variants at the tryptophan hydroxylase gene (TPH), serotonin receptor 2A (5.HT2A) have been associated with them in pilot studies (Serretti et al., submitted. a; Serretti et al., 2001a; Serrettiet aLlOO!b; Smeraldi et al., 1998; Zanardi et aJ., 2000; Zanardi et al., 2001). These studies demonstrated that treatment with SSRls appears to be, at leas! to some extent, under generic influence and preliminary data identified possible liability genes, Nevertheless, serotonin transporter gene variant (5-HTTPR) and tryptophan hydroxylase polymorphic gene (TPH) explain 7% and 5% of the total variance of antidepressant response respectively. Other liability genes could be therefore involved. Probab
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20127 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.