Objective
The biological processes that occur at the cell surface have profound effects on the behaviour of cells and organisms. Today, cell surface phenomena mediated by adhesion receptors are major areas of research in all disciplines of modern biology, ranging from physiology and development to immunology, neurobiology and cancerology. The past 10 years have witnessed tremendous progress in our knowledge of adhesion molecules and their functions. Cell adhesion receptors include different families of proteins such as integrins, cadherins, molecules of the Ig superfamily (also referred as to CAMs), syndecans and Eph receptors. These molecules represent an integrated sensory system for transducing positional information of crucial importance in controlling the correct organization of the body plan during development and several patho-physiological processes in adult organisms. Adhesion molecules act as genuine surface receptors which convey biochemical signals inside the cells regulating tyrosine kinases/phosphatases, GTPases, lipid metabolisms, intracellular ionic concentrations.
Although the basic molecular events flowing from single activated adhesion receptors have been partially described, new questions arise from this work that will represent major research topics in the next few years. It is clear that signalling pathways by adhesion receptors do not function separately, but are highly integrated with that of other surface receptors and the underlying cytoskeleton. A paradigmatic example of such integration is the absolute requirement of cell adhesion for proliferative response to mitogens. It is, thus, crucial to elucidate the structural basis of adhesive receptors cross-talk with other cell surface molecules such as cytokine, growth factor receptors, and other adhesion receptors. On the other hand, it is now clear that adhesion receptors can affect gene expression and identification of the genes whose expression is specifically regulated by adhesion is now becoming a central issue. The third crucial issue concerns the identification of the receptor-proximal molecular events connecting adhesive receptors to the intracellular signalling machinery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.