Cytochromes P450 (abbrev. P450) are the most important enzymes of metabolism of drugs, environmental pollutants and many toxicants as chemical carcinogens (e.g. polycyclic aromatic hydrocarbons, nitrosamines). On the other hand, the P450s are also involved in many vital functions in the body such as in the biosynthesis of steroid hormones, prostaglandins or thromboxanes. Hence, the importance of this subject for understanding of molecular mechanisms of processes involved e.g. in hormone biosynthesis, drug metabolism or in the activation of chemical carcinogens is crucial.
This Conference is focussed ( i) on the insight into the nature of structure/function relationship of the P450 enzymes, (ii) on the role of understanding molecular mechanisms and the processes involved.