Skip to main content
Ir a la página de inicio de la Comisión Europea (se abrirá en una nueva ventana)
español es
CORDIS - Resultados de investigaciones de la UE
CORDIS
Contenido archivado el 2024-05-21

Molecular mechanisms and signification of leafy (lfy) movement

Objetivo

In Arabidopsis, the meristem identity gene LEAFY (LFY) can exert non-cell autonomous effects during floral development. Genetic chimera have shown that these effects are mediated by the trafficking of LFY protein from cells where its mRNA is expressed to cells where RNA is not detected. In plants, such non-autonomous effects mediated by the intercellular transfer of transcription factors have also been reported for KNOTTED1 (KN1) in maize, and DEFICIENS (DEF) and GLOBOSA (GLO) in snapdragon. However, the mechanism and the significance of these movements remain enigmatic. By using LFY as a paradigm, I propose to develop three lines of experiments to address these questions:
1) I will determine by targeted mutagenesis the cis-determinants for transcription factors movement and retention;
2) investigate the signification of LFY movement in physiological conditions by expressing a movement-deficient LFY mutant mini-gene in a fly background;
3) isolate trans-acting factors of LFY movement by using two novel genetic screens.

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Datos no disponibles

Convocatoria de propuestas

Datos no disponibles

Régimen de financiación

RGI - Research grants (individual fellowships)

Coordinador

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Aportación de la UE
Sin datos
Dirección
Spemannstrasse 35
72076 TUEBINGEN
Alemania
Coste total
Sin datos