Objective
The objectives of the present project are the development of highly efficient and enantioselective 1,4- additions of Grignard reagents and other organometallic reagents (RZnX, RLi, RBX_2 and R_3Al) to enones using chiral copper catalysts based on phosphoramidites and related chiral ligands A further goal is to exploit the modular architecture of phosphoramidite ligands to generate also libraries of chiral ligands in order to fine tune the copper/ligand combination for a particular type of organometallic reagent or class of substrates. By screening a variety of phosphoramidites (PN ligands) as well as related phosphites and phosphonates we will select those ligands that combine high turnover with high regioselctivity (1,4- vs 1,2-addition) in the Cu(I)-and Cu(II)-catalysed addition. Small catalyst libraries will be constructed for this purpose. Once suitable active systems have been found, optimization of the enantioselectivity of the copper-ligand combination will be performed. Any major improvement towards enantioselctive catalytic 1,4-addition of Grignards is expected to be highly relevant for the field and if we succeed in reaching the 95% ee level it will undoubtedly be a breakthrough in catalytic asymmetric C-C bond formation with important consequences for organic synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9747 AG GRONINGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.