Objective
In contrast to previous views, recent studies have shown that bacterial chromosome partition is active process. All studies done so far have focused on unicellular bacteria with circular chromosome. However, they revealed that the functional significance of partition proteins differs for different bacterial species. This proposal focuses on partitioning of the Streptomyces linear chromosome during the complex life cycle of this mycelial organism. Recently identified Streptomyces chromosome partition genes, parA and parB and their products, ParA and ParB, will be further characterized, leading to an analysis of the role of these proteins during partition complex formation and regulation of their expression during Streptomyces growth and development. Putative mechanism of coupling chromosome replication to partition involving the replication initiator protein (DnaA) will be explored. The following aims of the research project are planned:
(i) analysis of interactions of ParA/ParB,
(ii) the sub cellular localization of ParA and ParB as well as DnaA, particularly in mycelia compartment undergoing multiple cell division, and
(iii) study of developmental regulation of transcription from parAB promoter. The proposed study should provide insight not only into Streptomyces linear chromosome partitioning but also into its correlation with DNA replication and colony sporulation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics chromosomes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NR4 7UH NORWICH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.