Objective
Prokaryotic toxin Kid inhibits proliferation of eukaryotic cells and triggers apoptosis in human cells, whilst its natural antidote Kis, protects from these effects. Modulation of the intracellular relative levels of Kid and Kis have been used to selectively regulate cell proliferation (or cell death) in eukaryotic cells. This approach may allow targeted cell ablation of cancer cells or of specific cell lineage during development and has potential in gene therapy strategies and in developmental studies. To achieve these goals it is important to understand Kid s mode of action in eukaryotic cells. Preliminary results show that Kid inhibits eukaryotic DNA replication, arrests yeast cells in G1 phase of the cell cycle and inhibits proliferation of human cells which die by apoptosis. On the basis of these observations, the main purpose of this project is to investigate the precise mechanism of action of Kid in human cells and how it is linked to inhibition of cell proliferation and to the activation of cell death.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 2XZ CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.