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Zawartość zarchiwizowana w dniu 2024-05-24

Kid mechanism of action in human cells-links to apoptosis

Cel

Prokaryotic toxin Kid inhibits proliferation of eukaryotic cells and triggers apoptosis in human cells, whilst its natural antidote Kis, protects from these effects. Modulation of the intracellular relative levels of Kid and Kis have been used to selectively regulate cell proliferation (or cell death) in eukaryotic cells. This approach may allow targeted cell ablation of cancer cells or of specific cell lineage during development and has potential in gene therapy strategies and in developmental studies. To achieve these goals it is important to understand Kid s mode of action in eukaryotic cells. Preliminary results show that Kid inhibits eukaryotic DNA replication, arrests yeast cells in G1 phase of the cell cycle and inhibits proliferation of human cells which die by apoptosis. On the basis of these observations, the main purpose of this project is to investigate the precise mechanism of action of Kid in human cells and how it is linked to inhibition of cell proliferation and to the activation of cell death.

Dziedzina nauki (EuroSciVoc)

Program(-y)

Temat(-y)

Brak dostępnych danych

Zaproszenie do składania wniosków

Brak dostępnych danych

System finansowania

RGI - Research grants (individual fellowships)

Koordynator

MEDICAL RESEARCH COUNCIL
Wkład UE
Brak danych
Adres
Hills Road
CB2 2XZ CAMBRIDGE
Zjednoczone Królestwo
Koszt całkowity
Brak danych