Further development of the film method for modelling membrane protein three-dimensional structures

Informations projet

PELLEGRINI-CALACE MA

N° de convention de subvention: HPMF-CT-2002-01754

Projet clôturé

Date de début 1 Février 2002

Date de fin 31 Janvier 2003

Financé au titre de

• Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Coût total € 53 936,00

Contribution de l’UE € 53 936,00

Coordonné par

UNIVERSITY COLLEGE LONDON
Royaume-Uni

Objectif

The main objective of our research project consists in deriving an ab initio method able to predict, at an acceptable level of accuracy , folding and topology of membrane proteins. This will be carried out by improving FILM (Folding in Lipid Membranes), a knowledge-based method previously developed to predict 3-D structures of small membrane proteins. With this aim, energy functions able to describe folding and packing interactions inside the membrane will be derived by the approach used in the current version of FILM. A data set composed of macromolecules with known topology and high-resolved 3-D features will be created for each class of membrane proteins. Furthermore, topology,folding and packing will be studied by statistical analysis of each set and converted in interaction energy functions by applying the inverse Boltzmann equation. The novel interaction energies will be added to the earlier force field and the improved method will be validated on proteins having high-resolved 3-D structure available at PDB. Finally, also peptides forming oligomeric channels, such as melittin and alamethicin will be considered and a proper energy functions will be developed, so that the method could be reliably applied to the whole family of membrane proteins.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences naturelles › mathématiques › mathématiques pures › topologie
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines
• sciences naturelles › sciences biologiques › biochimie › biomolécule › lipides

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Programme(s)

• FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Thème(s)

Données non disponibles

Appel à propositions

Données non disponibles

Régime de financement

RGI -

Coordinateur

UNIVERSITY COLLEGE LONDON

• Contribution de l’UE: Aucune donnée
• Adresse: Gower Street 5 ; WC1E 6BT London ; Royaume-Uni
• Coût total: Aucune donnée