Objective
The objective of the project is to combine chemical and enzymatic methods to show the complementarity of both techniques in the field of asymmetric synthesis. It will consist of two parts :
1.- Synthesis of chiral sulfondiamides (12-15 months). Several possibilities will be considered for their preparation in optically active form, such as enzymatic resolution of racemic mixtures or resolution by salt formation (0-3 months), imitation of an optically active sulfimide (0-3 months), and separation of enantiomers by preparative chiral HPLC (0-3 months). These sulfondiamides will be modified, so that the nitrogen atom bears different aryl rings (such as phenols and pyridines), able to chelate metals (3-6 months).
2 . - Once several promising sulfondiamides have been prepared, they will be tested as chiral auxiliaries and ligands in catalysed asymmetric reactions in which sulfoximines have proven to be useful(9-12 months): for example, copper catalyzed enantio selective hetero-Diels-Alder reaction (3-6 months) and palladium catalysedallylic alkylation (3-6 months) .Several possibilities will be considered for the preparation ofchiral sulfondiamides, both CHEMICAL (salt resolution, starting from chiral sulfimides, and preparative HPLC) and ENZYMATIC (resolution and asymmetrization), as well as chemical MODIFICATION of previous ones. Then, they will be tested as ligands and auxiliaries in METAL-CATALYSED asymmetric reactions. For the fellow, this will represent an opportunity to complement his previous knowledge in biocatalysis with its application in the preparation of new ligands which can be further used in NON-ENZYMATIC CATALYSIS. Previous experience Prof. Bolm's research grouping this field will help him to get easily familiarized with this other kind of catalysis .For the host group, this will broaden the scope of its research line, including ENZYMATIC CATALYSIS as a (new for it) possibility to do asymmetric synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences catalysis biocatalysis
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Coordinator
52056 AACHEN
Germany
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